U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines—"everybody must get stoned"— is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery, published online in The FASEB Journal, may lead to new marijuana-like drugs for managing pain, stimulating appetite, and preventing marijuana abuse.
Studies show that the release of the body's own marijuana-like compounds is crucial to stress-induced analgesia the body's way of initially shielding pain after a serious injury.
Cannabinoid compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating key cell-signalling pathways.
Scientists from Hungary, Germany and the U.K. have discovered that our own body not only makes chemical compounds similar to the active ingredient in marijuana (THC), but these play an important part in maintaining healthy skin. This finding on "endocannabinoids" just published online in, and scheduled for the October 2008 print issue of, The FASEB Journal could lead to new drugs that treat skin conditions ranging from acne to dry skin, and even skin-related tumors.
"Our preclinical data encourage one to explore whether endocannabinoid system-acting agents can be exploited in the management of common skin disorders," said Tamás Biró, MD, PhD, a senior scientist involved in the research. "It is also suggested that these agents can be efficiently applied locally to the skin in the form of a cream."
Biró and colleagues came to this conclusion by treating cell cultures from human sebaceous glands (the glands that make the oil on our skin) with various concentrations of endocannabinoids (substances produced by the body that are similar to the active ingredient in marijuana).
Then they measured the production of lipids (fat cells, such as those in skin oil), cell survival and death, and changes in gene expression and compared these outcomes to those in an untreated control group.
"This research shows that we may have something in common with the marijuana plant," said Gerald Weissmann, MD. "Just as THC is believed to protect the marijuana plants from pathogens, our own cannabinoids may be necessary for us to maintain healthy skin and to protect us from pathogens ."
The CB1 receptor
The CB2 receptor
The possibility of CBn receptors
Docosatetraenylethanolamide and Homo-g-linoenylethanolamide
Some Proposed roles of the endogenous cannabinoid system
Learning and synaptic plasticity
Allergy and regulation of inflammation
Source: Federation of American Societies for Experimental Biology
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