Ganja Vibes Blog

'Everybody must get stoned' ~ Bob Dylan

http://www.physorg.com/ U.S. and Brazilian scientists have just proven that one of Bob Dylan's most famous lines—"everybody must get stoned"— is correct. That's because they've discovered that the brain manufactures proteins that act like marijuana at specific receptors in the brain itself. This discovery, published online in The FASEB Journal, may lead to new marijuana-like drugs for managing pain, stimulating appetite, and preventing marijuana abuse. Studies show that the release of the body's own marijuana-like compounds is crucial to stress-induced analgesia the body's way of initially shielding pain after a serious injury. Cannabinoid compounds have been shown to inhibit the growth of tumour cells in culture and animal models by modulating key cell-signalling pathways. Scientists from Hungary, Germany and the U.K. have discovered that our own body not only makes chemical compounds similar to the active ingredient in marijuana (THC), but these play an important part in maintaining healthy skin. This finding on "endocannabinoids" just published online in, and scheduled for the October 2008 print issue of, The FASEB Journal could lead to new drugs that treat skin conditions ranging from acne to dry skin, and even skin-related tumors. "Our preclinical data encourage one to explore whether endocannabinoid system-acting agents can be exploited in the management of common skin disorders," said Tamás Biró, MD, PhD, a senior scientist involved in the research. "It is also suggested that these agents can be efficiently applied locally to the skin in the form of a cream." Biró and colleagues came to this conclusion by treating cell cultures from human sebaceous glands (the glands that make the oil on our skin) with various concentrations of endocannabinoids (substances produced by the body that are similar to the active ingredient in marijuana). Then they measured the production of lipids (fat cells, such as those in skin oil), cell survival and death, and changes in gene expression and compared these outcomes to those in an untreated control group. "This research shows that we may have something in common with the marijuana plant," said Gerald Weissmann, MD. "Just as THC is believed to protect the marijuana plants from pathogens, our own cannabinoids may be necessary for us to maintain healthy skin and to protect us from pathogens ." http://www.erowid.org/plants/cannabis/cannabis_pharmacology2.shtml Cannabinoid receptors The CB1 receptor The CB2 receptor The possibility of CBn receptors Endocannabinoids Anandamide 2-arachidonoyl-glycerol Palmitoyl-ethanolamide Docosatetraenylethanolamide and Homo-g-linoenylethanolamide Oleamide Some Proposed roles of the endogenous cannabinoid system Learning and synaptic plasticity Pain Vision Neuroprotection Allergy and regulation of inflammation Reproduction Source: Federation of American Societies for Experimental Biology

Adam Ferrara

Actor & Comedian Adam Ferrara Adam had an artistic bohemian upbringing in the Los Feliz neighborhood of L.A while his parents guests to the house included the likes of Robert Crumb, Robert Williams, Matt Groening, and Timothy Leary to name a few. http://www.funnyordie.com/embed/138d58b320

Truth in disclosure

Joe Rogan

Joe Rogan is an American comedian, video blogger, actor, writer, podcaster, and martial artist. One of the recurring themes in his stand-up comedy and life is the use and support of cannabis, psilocybin mushrooms, and DMT. Rogan supports the medical and recreational use of cannabis.He has also starred in the marijuana documentary The Union: The Business Behind Getting High. Rogan was featured in the 2010 History Channel documentary, Marijuana: A Chronic History, as an advocate of legalized medical use of marijuana. He is also the presenter of the 2010 documentary, DMT: The Spirit Molecule, released in October 2010. From MMA to Newsradio...Love this guy! Joe Rogan on Legalizing Marijuana [youtube http://www.youtube.com/watch?v=4fA-o6tSdmU&w=420&h=315] Joe Rogan on Occupy Wall Street [youtube http://www.youtube.com/watch?v=DjMcDXGkR8I&w=420&h=315]

Tetrahydrocannabinol

Tetrahydrocannabinol, also known as THC, Δ9-THC, Δ9-tetrahydrocannabinol (delta-9-tetrahydrocannabinol), Δ¹-tetrahydrocannabinol (using an older numbering scheme), or dronabinol, is the main psychoactive substance found in a variety of plants; most abundantly so in the Cannabis plant. It was isolated by Raphael Mechoulam and Yechiel Gaoni from the Weizmann Institute in Rehovot, Israel in 1964. In pure form it is a glassy solid when cold and becomes viscous and sticky if warmed. THC has a very low solubility in water, but a good solubility in most organic solvents such as ethanol or hexane. As in the case of nicotine and caffeine, THC's most likely function in Cannabis is to protect the plant from herbivores or pathogens [1]. THC also possesses high UV-B (280-315 nm) absorption properties, protecting the plant from harmful radiation. Pharmacology Its pharmacological actions are the result of its binding to the cannabinoid receptor CB1, located in the brain. The presence of these specialized receptors in the brain implied to researchers that endogenous cannabinoids were manufactured by the body, so the search began for a substance normally manufactured in the brain that binds to these receptors, the so-called natural ligand or agonist, leading to the eventual discovery of anandamide, 2 arachidonyl glyceride (2-AG) and other related compounds. This story resembles the discovery of the endogenous opiates (endorphins, enkephalins, and dynorphin), after the realization that morphine and other opiates bound to specific receptors in the brain. THC has analgesic effects that, even at low doses, causes a "high", and medical cannabis can be used to treat pain. Other effects include: relaxation; euphoria; altered space-time perception; alteration of visual, auditory, and olfactory senses; disorientation; fatigue; and appetite stimulation. It also has anti-emetic properties, and also may reduce aggression in certain subjects. Toxicity According to the Merck Index, 12th edition, THC has a LD50 value of 1270 mg/kg (male rats) and 730 mg/kg (female rats) administered orally dissolved in sesame oil. If this were scaled up to an adult human, the LD50 would be between approximately 50 and 86 g for a 68 kg (150 lb) female or male person respectively. This would be equivalent to 1-1.8 kg of cannabis with a 5% THC content (roughly average) taken orally. The LD50 value for rats by inhalation of THC is 42 mg/kg of body weight. It is important to note, however, that toxicity studies in animal models do not necessarily correlate to human toxicity. THC receptor distribution in the rat CNS is different from that of humans, meaning that there is the significant possibility that toxicity in humans varies from the published animal LD50 studies. There has never been a documented fatality from marijuana or THC overdose. Absorption is limited by serum lipids which can become saturated with THC, thus the inherent solubility may mitigate toxicity. Studies of the distribution of the cannabinoid receptors in the brain explain why THC's toxicity is so low (i.e., the LD50 of the compound is so large): parts of the brain that control vital functions such as respiration do not have many receptors, so they are relatively unaffected even by doses larger than could ever be ingested under any normal conditions. Research A number of studies indicate that THC may provide medical benefits for cancer and AIDS patients by increasing appetite and decreasing nausea. It has been shown to assist some glaucoma patients by reducing pressure within the eye, and is used in the form of cannabis by a number of multiple sclerosis patients to relieve the spasms associated with their condition. Studies also indicate a variety of negative effects associated with constant, long-term use, including short-term memory loss. However, other studies have refuted this, claiming the MRIs of long term users show little or no difference to MRIs of the non-using control group. Although using positron emission tomography (PET), at least one study indicates altered memory-related brain function in marijuana users . The long-term effects of THC on humans have been disputed because its status as an illegal drug makes research difficult. Preliminary research on synthetic THC has been conducted on patients with Tourette syndrome, with results suggesting that it may help in reducing nervous tics and urges by a significant degree. Animal studies suggested that Marinol and nicotine could be used as an effective adjunct to neuroleptic drugs in treating TS. Research on twelve patients showed that Marinol reduced tics with no significant adverse effects. A six-week controlled study on 24 patients showed the patients taking Marinol had a significant reduction in tic severity without serious adverse effects. Seven patients dropped out or had to be excluded from the study, one due to adverse side-effects. More significant reduction in tic severity was reported with longer treatment. No detrimental effects on cognitive functioning and a trend towards improvement in cognitive functioning were reported during and after treatment. Marinol's usefulness as a treatment for TS cannot be determined until/unless longer controlled studies on larger samples are undertaken. Recent research has shown that many adverse side effects, generally known as the "stoner" stereotype, fail to hold up to the scientific method. Recent studies with synthetic cannabinoids show that activation of CB1 receptors can facilitate neurogeneration, as well as neuroprotection, and can even help prevent natural neural degradation from neurodegenerative diseases such as MS, Parkinson's, and Alzheimer's. This, along with research into the CB2 receptor (throughout the immune system), has given the case for medical marijuana more support. In in-vitro experiments THC at extremely high concentrations, which could not be reached with commonly consumed doses, caused inhibition of plaque formation, the cause of Alzheimer's disease, better than currently approved drugs.[8] THC may also be an effective anti-cancer treatment, with studies showing tumor reduction in mice, conducted in 1975.[9] Chemical name (−)-(6aR,10aR)-6,6,9-trimethyl- 3-pentyl-6a,7,8,10a-tetrahydro- 6H-benzo[c]chromen-1-ol Chemical formula C21H30O2 Molecular mass 314.46 g/mol Glass transition 9.3 °C Boiling point 155-157 °C (vacuum, 0.07 mbar) Solubility (water) 2.8 mg/L (23 °C) Solubility (saline) 0.77 mg/L (NaCl, 0.15 M) pKa 10.6 log P 3.78 (water @ pH 7 / octanol) CAS number 1972-08-3

The Low Down on Lindsay Lohan

With what's been coming hot off the press regarding our dear, child to sex siren, actress Lindsay Lohan's beautiful pictorial début in Playboy: BEHOLD an "In the news with Lindsay Lohan" montage! Here's the wanna be Rock 'n Rolla, yet, not so song birds skinny on the lately... Lindsay Lohan’s "Marilyn Monroe-Inspired" Playboy Pictorial To Run in Jan Issue ORIGINAL SHOOT - Hef Did Not Approve...a reshoot was ordered, rightly so, Hugh is THE MAN for good reason. Although it's not hard to see this first shoot was executed terribly.
Lindsay Lohan's "Marilyn Monroe-Inspired" Playboy Pictorial To Run in January Issue [PICS] Hosted by Blog Certified Mr. Hefner proclaimed the second shoot bonafied & sent the spread into production. Not a bad remake, Ms. Lohan. The originator Ms. Marilyn Monroe~ Lindsay Lohan has caused so many heads to spin, someone thought it obligatory to bestow a strain unto her amazing beguiling character. Wednesday, October 12, 2011 source:http://thechronic-le.blogspot.com/2011/10/medical-marijuana-strain-review-lindsay.html Medical Marijuana Strain Review: Lindsay Lohan Overview: I guess it was just a matter of time before America's #1 skank Linday Lohan got her own medical marijuana strain, unfortunately, much like the actual person, it is a bit of a disappointment. Looks: Lindsay Lohan is a beautiful strain with short, stubby and super dense light green leaves that are covered in a light frost and plenty of rust-colored hairs that come tangling out of the buds. Taste/Smell: The taste was a little bit hashy and a little bit spicy. Not really a strong flavor here, but not entirely unpleasant. Buzz: Lindsay Lohan has the looks and a fairly decent taste, but the buzz is where it falls short. It made me super lethargic and sleepy. I wasn't good for anything for the rest of the day. Not only did these buds shut my body down, but my mind was also slowed down which is unusual for me because weed usually gets my creative juices flowing and gets me thinking. This strain might be good for insomniacs looking for relief, but I probably wouldn't recommend it for any other medical uses and I have a feeling it could make the symptoms of depression even worse. Overall Grade: C- [youtube http://www.youtube.com/watch?v=_i5uCL5uZaQ&w=560&h=315] No word has been confirmed as to whether or not Lindsay has penned the possible penis pleaser.... To be continued. WE love you Lindsay!

Ganja Vibes

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